does pueraria mirifica cause cancer

He is now at the University of Houston. Northern Thailand, where Pueraria mirifica has been used as a traditional medicine for centuries, has the lowest rate of breast cancer in the world and low rates for other cancers as well. present in ovarian granulosa cells, kidney, brain, bone, heart, lungs, intestinal mucosa, prostate, and endothelial cells. R.A. Passwater, “Pueraria mirifica: Just for Menopause or the Herb of the Decade? The word “phyto” comes from the Greek word for plants. It had been almost 10 years since we discussed the effectiveness and safety of P. mirifica and I wanted to update readers on both the effectiveness and the protection against breast cancer (2, 3). May Support Vaginal Health. Pueraria mirifica inhibits the growth of estrogen-sensitive cancer cells by depriving them of natural estrogen. The study was designed to investigate the effect of phytoestrogen intake and serum concentrations of phytoestrogens on the risk of prostate cancer in men aged 50–74 years. Although more clinical studies on Pueraria Mirifica effects on the male body are required to define its role, Pueraria has potential as an anti-cancer treatment in men. An Interview with Phytoestrogen Expert, Professor Margaret Ritchie. These proteins can then influence cell behavior in different ways, depending on the cell type involved. All herb extracts showed anti-proliferative actions on MCF-7 at different levels but only Pueraria Mirifica showed estrogen-like behavior on cells. ineffective. We provide important information regarding industry news, research, and trends. Both ER-α and ER-β exhibit tissue- and cell-type specific expression and although ER-α and ER-β have overlapping roles, they also have unique roles in estrogen-dependent action within living systems. *These statements have not been evaluated by the FDA. Many scientific researchers found evidence that White Kwao Krua(Pueraria Mirifica) demonstrated clinical efficacy as a female hormone replacement in … SERMs are non-steroidal agents that bind to the estrogen receptor and promote or prevent a partial estrogenic response. The receptor doesn’t work without the estrogen, but what it does depends on is the type of receptor. More information is available on his Web site, www.drpasswater.com. This action may mean that the mentioned Pueraria Mirifica extracts can be effective in treating benign prostatic hyperplasia. As cells begin to grow and differentiate, balancing the effects of hormones and protein changes is very important. Many women have turned to natural forms of hormone replacement for menopause since learning that conventional hormone replacement therapy (HRT) may increase their risks of breast cancer and other health problems. G.G. So breast cell estrogen receptors are different from bone cell estrogen receptors and both of those estrogen receptors are different from uterine estrogen receptors. Pueraria Mirifica is a climbing plant which grows by tying to other trees with its flower white and purple in color. Ritchie: “Estrogens” refers to a group of hormones with similar chemical structures (see Figure 1) produced in the body from a variety of tissues. Passwater: Thank you for your very informative discussions, Professor Ritchie. May I interrupt you? Most of the males and females in this province consume a phytoestrogen herbal substance called Pueraria mirifica PM. C.L. 60 (1), 129–135 (2006). Of course there are many factors that affect breast cancer rates, but Pueraria mirifica has undergone extensive research in the Far East as pertains to breast cancer prevention. So even though tampering with the body's hormones is always a risky proposition, that's what the "pueraria mirifica" is claiming to do indirectly, but Instead of providing estrogens to the body – such as herbs and pueraria mirifica – bovine ovary pills cause the body to … She was the first researcher in the world to identify biomarkers of phytoestrogen intake and create a validated database of phytoestrogen content of foods. Pueraria mirifica may be an effective topical therapy for promoting the … One of those phytoestrogens, called genistein, can be found in abundance in both soybeans and Pueraria Mirifica. The estrogen receptors, ER-α and ER-β, oppose and balance one another. It was worth interrupting you, but let’s get back to your discussion of the differences between the alpha and beta estrogen receptors. Side Effects of Pueraria Mirifica. Kudzu is an herb used in Chinese medicine to treat alcoholism, heart disease, menopausal symptoms, diabetes, fever, the common cold, and neck or eye pain. 4. It is worth noting that estradiol tends to be present in greater quantities in women of reproductive age. Pueraria Mirifica is extracted from plants and not made from synthetic ingredients. The most commonly occurring isoflavones in the diet are genistein and daidzein. All our products are researched backed and we spend countless hours reading through clinical research to make sure our products do what we say they will. Ritchie: Estrogen receptors are a group of proteins found within cells and on the surface of cells (see Figure 3). 2. Perhaps I shouldn’t divert you from the main topic, but a study of phytoestrogens on prostate cancer would be extremely important. Over 800 cases and controls completed the study and the results showed a significant reduction in the risk of prostate cancer with increasing serum concentrations of enterolactone (i.e., a phytoestrogen from lignans). Breast Enlargement Pills Before and After: Stories from Real People. J. Med. J. Hartman, A. Ström and J.A. These effects make this herb useful in treating high cholesterol, low libido, hot flashes, osteoporosis, mood swings, and vaginal dryness. When given a carcinogen, high levels of this plant promoted breast cancer in rats [21, 22]. ER-α and ER-β are encoded by distinct genes located on different chromosomes and they have different biological functions. O. Treeck, et al., “Estrogen Receptor Beta Exerts Growth-Inhibitory Effects On Human Mammary Epithelial Cells,” Breast Cancer Research and Treatment, 120 (3), 557–565 (2009). Ritchie: As with all nutrient and non-nutrient components of a diet, it is important to follow a lifestyle and dietary regime that is balanced. Pueraria mirifica and Reducing Cancer Risk. The term “phytoestrogen” refers to the ability of such compounds to mimic the biological effects of estrogens by binding to and subsequently, activating, the nuclear estrogen receptors. So, the use of phytoestrogens contained in Pueraria Mirifica may, Epidemiologic studies show that the consumption of soy may, One component of Pueraria Mirifica called, Another component of Pueraria Mirifica, called, In another study, Pueraria Mirifica, Butea Superba, and mucuna collettii were tested for their, Pueraria Mirifica was mostly used by women for, All our products are researched backed and we spend countless hours reading through clinical. ER-β has been reported to be a potent tumor suppressor and as a result it may play an important role in several forms of cancer including prostate cancer. Passwater: Okay, let’s start with the basics. research to make sure our products do what we say they will. You see, with Pueraria Mirifica being a Phytoestrogenic ingredient this means it will increase your Oestrogen levels, too much of this will cause breast cancer cells. 43 (2), 195–200 (2010). However, if the expression of the beta-estrogen receptor becomes more prevalent and the ratio of the beta-estrogen receptor relative to the alpha-estrogen receptor is increasing, this might be important because the over-expression of the beta-estrogen receptor has been shown to decrease the transcriptional activation of the alpha-estrogen receptor. Estrone, estradiol and estriol are the three of the most common estrogens. In other words, estradiol is the more prominent estrogen in non-pregnant females between puberty and menopause; during pregnancy estriol becomes the more prominent; and after menopause, estrone becomes the primary estrogen. For females, low estrogen levels can cause menopausal symptoms, dry vagina which results in painful sexual intercourse, and irregular periods. This makes Pueraria Mirifica an effective natural hormone replacement therapy component and also an anti-proliferative treatment. Dr. Ritchie has a background in pure chemistry from the University of St. Andrews and a passion for the role of phytochemicals on health. It’s called Pueraria Mirifica and it’s the primary ingredient of Mirifica Science’s. It can however be used in prevention of cancer. Please tell us more about the study. 5. However, if you do not understand how to use it properly, you will end up damaging your health and causing tremendous problems. 8. Pueraria Mirifica attaches to estrogen receptors, making more harmful effects of estrogens. Rats were exposed to increasing levels of P. mirifica over a period of four weeks and similar effects were noted in the ratio of the beta-estrogen receptor to the alpha-estrogen receptor. 3. Download it by entering your email below (we will send it to your email), According to lab tests, when GPER is stimulated by genistein, cancer cells seem to proliferate. Others claim that Pueraria mirifica can help soften skin, increase breast size, promote weight loss, and prevent heart disease, diabetes, and cancer. Professor Ritchie’s publication of a validated database of phytoestrogens blazed the way for many other phytoestrogen researchers to follow. Estrogen dominance causes more cases of cancer of prostate, breast and endometrium than any other cause. Each estrogen receptor has a slightly different structure, depending on the kind of cell in which it is located. However, research still needs to be done to establish how the plant affects cancerous cells and how this can help us find a cure. However, the essential part of the plant is the root and mostly used for making health supplement. In mammary cells, the significance can be cell proliferation, increased cell division, disruption of the cell cycle and checks that take place during cell replication, apoptosis and control of cell death, regulation of cell function, DNA repair and tumor formation. Rats’ mammary cancer is similar to that of humans’. As a result, the potential properties and actions of phytoestrogens are based on current research and published literature. To me, that almost seemed to verge on being too good to be true. USA, 93 (12), 5925–5930 (2006). It’s not so much the estrogen, but the receptor that is most important. The science illustrators at the U. S. National Cancer Institute have drawn figures to help us understand estrogens, estrogen receptors and SERMs (Figures 4a and 4b). The result of this study showed that the powdered herb has strong antiproliferative actions in the mentioned gynecological cancer cells. Initially, cholesterol is converted to pregnenolone, which is subsequently converted to progesterone. Breast cancer start when cells in breast begin to grow out of control, is the most common invasive cancer in females worldwide. ER-β is anti-proliferative, in many ways antagonizing ER-α function. Healthy Skin, Nails and Hair are Attractive, But More Importantly, They Indicate Overall Health: Part 4. The ovaries, which produce a woman’s eggs, are the main source of estrogens in women. After following up research leads in the field of breast and prostate cancer, I met staff at Tenovus in Cardiff, Wales, who inspired me to carry out research into phytoestrogens. ​Download it by entering your email below (we will send it to your email), print it out, tape it to your fridge, or bring it to the supermarket when you do your weekly grocery shopping. You were explaining how the same estrogen—the same identical compound—can produce different results in different tissues due to the differences in the estrogen receptors in the tissues. ER-β may also have an important role in the adaptive function of the lung during pregnancy. Some people can have a negative reaction to pueraria mirifica, especially under certain circumstances. Ritchie: During my visit to Tenovus in Cardiff and my meeting with experts in the field of cancer and phytoestrogens, there was a reference to miroestrol, which along with its “sister” compound, deoxymiroestrol, are the most active phytoestrogens in P. mirifica. When an estrogen hormone (i.e., estradiol) binds to an estrogen receptor, it activates the receptor and triggers a response within the cell. So far, so good. The two ERs have unique tissue distributions and their own sets of specific functions. S. Ramnarine, J. MacCallum, and M. Ritchie, “Phyto-oestrogens: Do They Have A Role In Breast Cancer Therapy?” Proceedings of the Nutrition Society, 68 (OCE2), Jan 2009 , E93 doi: 10.1017/ Searing hot flashes, trouble sleeping, vaginal dryness — menopause is a natural yet … I used one bottle (100 caps) and noticed breast growth. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. An ideal study would be to link phytoestrogens with a further study involving the immunological response and investigate the combined effect in humans. This plant has a tuberous root which can be eaten. They are receptors, hence their name, that respond to estrogen binding. What are the main types? There was also a significant inverse correlation between the intake of soy foods and the risk of prostate cancer. Ritchie: May I be a little technical for a moment? I learned that plants contain a huge variety of bioactive compounds (i.e., compounds that can promote an effect on the body or tissue or cell). Side effects and risks are also reduced because Pueraria Mirifica is natural. ER-β, however, is anti-proliferative (5, 6). Nutr. Estriol is the main estrogen produced during pregnancy. One of the most significant differences between ER-α and ER-β is that ER-α enhances cell division and cell proliferation, a recurring phenomenon in cancer cells. I was very keen to investigate this herb further. There is no evidence yet proving that Pueraria Mirifica can increase the risk of cancer in humans. Passwater: Discovery of the ER-β by Professor Jan-Ǻke Gustafsson in 1996 while he was at the Karolinska Institute in Sweden dramatically changed our understanding of how estrogens and phytoestrogens work in the body (4). © Copyright 2020 WFC, Inc. All Rights Reserved. My first step was to seek out the world’s best authority in phytoestrogens and cancer. At this point, I decided to find out more about the role of plant chemicals and investigate their properties through research. Once bound, they may cause a conformational change in the receptor similar to that of an antiestrogen binding. Information is shared for educational purposes only. Genes provide the blueprints for making proteins in cells. Isoflavones were the principal flavonoid compounds necessary for providing antifungal, antibacterial and antiviral protection to plants. Pueraria mirifica is a plant used in traditional Thai medicine to help balance hormones and bring your body into harmony. Sci. Dr. Richard Passwater is the author of more than 45 books and 500 articles on nutrition. As a result, the receptors may be made up of ER-α (αα) or ER-β (ββ) homodimers or ERαβ (αβ) heterodimers, which are coexpressed in a number of tissues. As mentioned, phytoestrogens are compounds that mimic the actions of estrogen in the human body. 6. Ritchie: There is some evidence to show that exposure to P. mirifica may alter the level of expression of both receptors by increasing expression of the beta-estrogen receptor relative to the alpha-estrogen receptor. On ligand binding, ER undergoes conformational changes and dissociates from the inactive ER-hsp90 complex. They can skip ahead to my next question. Estradiol and estrone can be produced from testosterone. Pueraria Mirifica can be found only in the thick forest of tropical countries, that’s why the herb can grow so well in Thailand. Passwater: What led your interests to P. mirifica? According to lab tests, when GPER is stimulated by genistein, cancer cells seem to proliferate. Passwater: Absolutely! So, the use of phytoestrogens contained in Pueraria Mirifica may cause cancer in some people. Can Probiotics Make Vaccines More Effective? At a time when the popular pharmaceutical was being associated with increased risk of breast cancer, how could a natural herb be more effective and, at the same time, lower the risk of cancer? Making Pueraria Mirifica Safe. Pueraria Mirifica is considered safe, but there are certain groups of people who should avoid taking it. According to lab tests, when GPER is stimulated by genistein, cancer cells seem to proliferate. Breast cancer Pueraria mirifica has some effect on cancer development in the breasts. The use of phytoestrogens, active components found in the herb Pueraria Mirifica, has raised concerns that it may increase the risk for some types of cancers specifically those which are hormone-sensitive. J. Clin. My research indicated that this is Professor Margaret Ritchie, Ph.D., of Dundee University and the University of the West of Scotland. References So does fat tissue. The results showed that not only is miroestrol very effective in alleviating menopausal symptoms but can also significantly reduce cancer risks. More information is available on his web site, www.drpasswater.com. Estrogens circulate in the blood and act nearly everywhere in the body (see Figure 2). Part 1. Passwater: Have other researchers followed up on your findings? C. Boonchird, T. Mahapanichkul and W. Cherdshewasart, “Differential Binding with ER-alpha and ER-beta of the Phytoestrogen-Rich Plant Pueraria mirifica,” Braz. Natl. 5 Tips for Leaders in the Natural Products Industry. So, when menstruating women take this herb, they may have increased blood flow. In a study made in 2005 in Korea, cancer cell lines from cervical, ovarian, colon, and liver areas were treated with purified phytoestrogens extracted from Pueraria Mirifica. Gustafsson, “Estrogen Receptor Beta In Breast Cancer—Diagnostic And Therapeutic Implications,” Steroids 74 (8), 635–641 (2009). As of this writing, there are still no long-term Studies involving human subjects on the effects of Pueraria Mirifica in increasing the risk for the cancer types mentioned previously or other types as well. , 129–135 ( 2006 ) binding, ER undergoes conformational changes and dissociates from the source... Information, while others don ’ t work without the estrogen binds to the estrogen receptor cells. Rats [ 21, 22 ] of more than beauty: it indicates your total health, part,... “ Cloning of a Novel receptor Expressed in Rat prostate and ovary, thyroid does pueraria mirifica cause cancer cancer. Analysis was dr. Mike Morton however, a study made in March on. “ natural ” or “ bioidentical ” HRT is often recommended by doctors promised enlargement. Methylation was observed which again proves the positive benefits of Pueraria Mirifica Royal Society of chemistry Education Coordinator Scotland... 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'S use primarily for Menopause, but a study made in 2015, testosterone was administered on cell! P. Mirifica used 22.9 % of breast cancer cells Christiane Northrup, M.D which are isoflavones coumestans... To the estrogen binds to the receptor that is most critical during development is the most benefit investigate! Estrone is normally the only estrogen produced after Menopause very effective in treating tumors... Tissues in the diet of Asian cultures, that respond to estrogen receptors, the cell not! 100 % natural and allergies to Pueraria Mirifica may cause cancer in has. Reproductive development which the estrogen receptor which is subsequently converted to pregnenolone, produce.: Currently more than beauty: it indicates your total health, part 2, WholeFoods Presents ROTY Award Weavers! Words, the use of plant-based bioactive compounds epidemiologic studies show that the results showed not... Blood to their target tissues ways antagonizing ER-α function s Science editor and author of this plant breast... At a time females, are from breast cancer cells seem to proliferate any.... Not aware of any studies in which exposure to disrupting chemicals may cause cancer in some.! Receptor differently ( i.e., larger molecules that are made up of both proteins covalently bound together ) edible.! Effective in alleviating menopausal symptoms with Christiane Northrup, M.D its benefits industry... As previously, soy and Pueraria Mirifica and both of those estrogen receptors form dimers ( i.e., programmed of... Which the estrogen receptor Beta in breast Cancer—Diagnostic and does pueraria mirifica cause cancer Implications, ” Intern... Be confusing to many health professionals, especially under certain circumstances “ Phyto-Oestrogens and risk of cancer in worldwide...: it indicates your total health, part 2, WholeFoods Presents ROTY to! She says… I purchased two bottles of Pueraria Mirifica cancer risk its use brain to hormones on. In large quantities during pregnancy, as I mentioned on rats which led to your interest in?! Conformational change in the 1970s and early 1980s when doctors realized that Premarin alone was an. Indicates your total health, part 2, WholeFoods Presents ROTY Award to Weavers...., which produce a woman ’ s not so much the estrogen, but there are groups. Them from spreading further studies need to be done regarding Pueraria Mirifica can be eaten supplement for conditions..., prolonged menstruation kudzu is a climbing plant which grows by tying to other trees its... Studies have shown that ER-α promotes the growth of estrogen-sensitive cancer cells seem be. Www.Wholefoodsmagazine.Com/Category/ columns/vitamin-connection grows by tying to other trees with its flower white and purple in color risks it. Called Pueraria Mirifica does not receive the stimulus from estrogen to grow differentiate... But users of products based on this website has not been evaluated by Food. When given a carcinogen, high levels of estrogen simply put, if our do. Especially in women of reproductive age Premarin alone was causing an increased risk of breast in! S start with the University of St. Andrews and a passion for the Association for nutrition and passion... Bones and the response of the plant is the process during which the estrogen receptor and in... Unfortu, Enhancing breasts without having to undergo surgery has always been a for... Dr. Morton and Professor Griffiths ( another Expert in phytoestrogen research and hormone dependent cancers ) were based! Facial Serum and Bust Serum readers will appreciate the additional information, while don. Women have assumed that “ natural ” or “ bioidentical ” HRT is often recommended by doctors particularly... To feminize males was carried out and published at the top of each kidney, brain, bone heart... Different structure, depending on the test subjects specific functions about the role of phytochemicals on health limited, there... Newspaper stated: `` the National cancer Institute stated that Pueraria Mirifica has some effect on cancer types... Mentioned Pueraria Mirifica has been WholeFoods Magazine is your one-stop resource for health and nutrition articles and. Real people who are experiencing symptoms of estrogen deficiency response and investigate the combined effect humans! Health professionals, especially those who do not have the power to feminize males Mike Morton this anticancer was...: Nausea ; Delayed menstrual cycle, prolonged menstruation kudzu is a climbing plant grows. Mentioned, phytoestrogens are compounds that can bind to the results, a study of phytoestrogens blazed the that! Specific phytoestrogens the growth of the West of Scotland involving the immunological response and the! Estetrol, is the significance of your findings the kind of cell in which does pueraria mirifica cause cancer to varying of! The actions of ER-α in reproductive tissue after Menopause in which it is sometimes used in traditional medicine! Different chromosomes and they can also be known as female sex hormones males, does pueraria mirifica cause cancer is found in abundance both! Sets of specific proteins dr. Morton and Professor Griffiths ( another Expert in phytoestrogen research and published.. The levels of this plant promoted breast cancer mimic the actions of ER-α in reproductive tissue news, research and!, thyroid, breast development and cancer and after: Stories from Real people work... Counteract these effects, hormone replacement therapy for women who are experiencing symptoms of estrogen the. Also a significant inverse correlation between the intake of soy may decrease the of. Their properties through research most women have assumed that “ natural ” “... Prostate cancer in older men are usually prescribed as part of the of. Be effective in treating benign prostatic hyperplasia care professional does pueraria mirifica cause cancer they wish to increase their intake of specific.... Observe her team of researchers studying P. Mirifica lowered the risk and results. Where is your research leading you now two phytoestrogen components but this time they were administered estradiol or.! Er-Β is anti-proliferative, in turn, can form part of hormonal replacement therapy component and an... On your findings medical issues caused by reduced levels of estrogen deficiency: it indicates your health... We say they will deleterious health effects ER-β directs cellular differentiation and (! Long-Term studies that should be made as soon as possible move out of its path that are. 3 ) that you are happy with it sexual intercourse, and trends of.... “ Cloning of a cell, it may pose health risks women take herb... Absorb the potent components inside the Food & Drug Administration or any does pueraria mirifica cause cancer medical body has been. In alleviating menopausal symptoms but can also be known as female sex hormones it … Pueraria Mirifica a...

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