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Payers' coverage decision making on NGTS is challenging because this revolutionary technology pushes the very boundaries of the underlying framework used in coverage decisions. How Much is Todd Chrisleys Net Worth in 2023? to placebo plus carboplatin and paclitaxel in subjects with BRCA1 or BRCA2 mutation and Lowry, K. P., Geuzinge, H. A., Stout, N. K., Alagoz, O., Hampton, J., Kerlikowske, K., de Koning, H. J., Miglioretti, D. L., van Ravesteyn, N. T., Schechter, C., Sprague, B. L., Tosteson, A. N., Trentham-Dietz, A., Weaver, D., Yaffe, M. J., Yeh, J. M., Couch, F. J., Hu, C., Kraft, P., Polley, E. C., Mandelblatt, J. S., Kurian, A. W., Robson, M. E. Time Trends in Receipt of Germline Genetic Testing and Results for Women Diagnosed With Breast Cancer or Ovarian Cancer, 2012-2019. Among 146326 participants with median 14.6 follow-up years, 23067 incident cancers and 3152 cancer deaths were observed. External validation was performed by comparing results to observed rates in two independent sources. Breast cancer treatment according to pathogenic variants in cancer susceptibility genes in a population-based cohort. Sequencing results were confirmed by in-house developed full high resolution DNA melting (HRM) analysis. Ghataorhe, P., Kurian, A. W., Pickart, A., Trapane, P., Norton, J. View details for DOI 10.1200/JOP.2015.009803, View details for PubMedCentralID PMC4957259, View details for DOI 10.1200/JCO.2016.34.15_suppl.1509, View details for Web of Science ID 000404665402059, View details for DOI 10.1200/JCO.2016.34.15_suppl.1512, View details for Web of Science ID 000404665402062, View details for DOI 10.1200/JCO.2016.34.15_suppl.5510, View details for Web of Science ID 000404711501186, View details for DOI 10.1200/JCO.2016.34.15_suppl.6501, View details for Web of Science ID 000404711503035, View details for DOI 10.1200/JCO.2016.34.15_suppl.6552, View details for Web of Science ID 000404711503080, View details for DOI 10.1200/JCO.2016.34.15_suppl.6553, View details for Web of Science ID 000404711503081, View details for DOI 10.1200/JCO.2016.34.15_suppl.1052, View details for Web of Science ID 000404665401172, View details for DOI 10.1200/JCO.2016.34.15_suppl.1010, View details for Web of Science ID 000404665401132, View details for DOI 10.1200/JCO.2016.34.15_suppl.1503, View details for Web of Science ID 000404665402054. The sensitivity analyses yielded similar results and showed no strong evidence of pleiotropic effect.Our MR study provides supportive evidence for a potential causal association with breast cancer risk for lifetime smoking exposure but not cigarettes per day among smokers. She was loving but tough. View details for DOI 10.1007/s11764-019-00820-7. The primary objective of the study is to assess the progression-free survival (PFS) of oral Patients with triple-negative breast cancer (TNBC), defined as lacking expression of the estrogen and progesterone receptors (ER/PR) and amplification of the HER2 oncogene, often have a more aggressive disease course than do patients with hormone receptor-positive breast cancer, including higher rates of visceral and central nervous system metastases, early cancer recurrences and deaths. compared with a placebo in treating postmenopausal women who have received hormone therapy Chen, Y., Kingham, K., Ford, J. M., Rosing, J., Van Dam, J., Jeffrey, R. B., Longacre, T. A., Chun, N., Kurian, A., Norton, J. Staton, A. D., Kurian, A. W., Cobb, K., Mills, M. A., Ford, J. M. Magnetic resonance galactography: A feasibility study in women with prior atypical breast duct cytology. The absolute benefits would increase to 4.8%-5.5% if the RS was 26+. There he met his wife just like his brother. However, SPLC risk factors have not been established and the impact of tobacco smoking remains controversial. View details for DOI 10.1016/j.ajhg.2021.05.013. We examined whether PV carriers received more intensive regimens (HR-positive, HER2-negative: 3 drugs including an anthracycline; TNBC: 4 drugs including an anthracycline and platinum) and/or less standard breast cancer agents (a platinum). In all racial/ethnic groups, the models overpredicted in cases whose personal and family histories indicated >80% probability of carriage. To evaluate patient experiences with decisions regarding radiation therapy (RT) for ductal carcinoma in situ (DCIS), and to assess clinician views on the role of RT for DCIS with favorable features in the present era.A sample of women with newly diagnosed breast cancer from the population-based Georgia and Los Angeles County Surveillance, Epidemiology, and End Results (SEER) registries were sent surveys approximately 2months after undergoing breast-conserving surgery (BCS), with a 70% response rate. [20], On September 6, 2018, Kurian announced he was taking extended time off from the company. also hope to understand more about the experience of individuals and families who undergoing for these diseases. Lu, Y., John, E. M., Sullivan-Halley, J., Vigen, C., Gomez, S. L., Kwan, M. L., Caan, B. J., Lee, V. S., Roh, J. M., Shariff-Marco, S., Keegan, T. H., Kurian, A. W., Monroe, K. R., Cheng, I., Sposto, R., Wu, A. H., Bernstein, L. Phase II Study of Gemcitabine, Carboplatin, and Iniparib As Neoadjuvant Therapy for Triple-Negative and BRCA1/2 Mutation-Associated Breast Cancer With Assessment of a Tumor-Based Measure of Genomic Instability: PrECOG 0105. However, little is known about how chemotherapy use and oncologists' recommendations have changed in recent years.We surveyed 5080 women (70% response rate) diagnosed with breast cancer between 2013 and 2015 and accrued through two Surveillance, Epidemiology, and End Results registries (Georgia and Los Angeles) about chemotherapy receipt and their oncologists' chemotherapy recommendations. However, he is an expert when it comes to his married life, wife and even children. View details for DOI 10.1001/jamaoncol.2021.6204. Model inputs were derived from clinical trials, large US cohort studies, registry, and claims data. Patient regret and prophylactic surgery use were low, and patients appropriately encouraged relatives to be tested for clinically relevant results. Despite their high level of worry, few responders said they would likely consider using assisted reproduction technologies such as a pregnancy surrogate (3%), cryopreservation of oocytes or embryos (8%), or pre-implantation genetic diagnosis (PGD) to select embryos without BRCA1/2 mutations (13%).Although they expressed substantial concern about transmitting BRCA1/2 mutations to their children, only a minority of the high-risk women surveyed were likely to consider currently available assisted reproductive strategies. A survival analysis approach was used that was designed specifically to assess the time-varying association of RRSO with breast cancer risk and accounting for other potential biases. The probability of a VUS increased with increasing number of genes tested; this effect was more pronounced for nonwhites than for whites (1.1% absolute difference in VUS rates testing BRCA1/2 vs. 8% testing 13 genes vs. 14% testing 28 genes), worsening the disparity.ConclusionIn this diverse cohort undergoing MGS testing, pathogenic variant rates were similar between racial/ethnic groups. Results were most sensitive to variations in our assumptions about the magnitude and duration of breast cancer risk reduction due to prophylactic oophorectomy.Life expectancy gains depend on the type of BRCA mutation and age at interventions. Kwong, A., Chau, W., Law, F. F., Kurian, A., Ford, J. M., West, D. W., Ma, E. K. Feasibility evaluation of an online tool to guide decisions for BRCA1/2 mutation carriers. Hazard ratios (HR) and 95% confidence intervals (CI) for tamoxifen versus AI were reported.Among 2,902 analyzed patients, the median age at diagnosis was 58.3years; 67.6% were non-Hispanic white, 22.3% Asian, 7.5% Hispanic, and 1.7% non-Hispanic Black. Women's decision-making around risk management will be monitored using questionnaires, completed at baseline (pre-appointment) and follow-up (one, three and twelve months after receiving their risk assessment). Karimi, Y., Blayney, D. W., Kurian, A. W., Rubin, D., Banerjee, I. In a multivariable model adjusted for age and subtype, there was no interaction between family history extent and PV prevalence for any gene except PALB2 (P = .037).Extent of family cancer history is not differentially associated with PVs across established breast cancer susceptibility genes and cannot be used to personalize genes selected for testing. View details for DOI 10.1001/jamasurg.2016.4749, View details for Web of Science ID 000398101400016, View details for Web of Science ID 000398947202110. An adoption timeline was constructed.Sixty-nine payers had a sequencing policy. Chandler, Y., Schechter, C., Jayasekera, J., Isaacs, C., Kurian, A. W., Cadham, C., Mandelblatt, J. Racial/ethnic differences in cancer diagnosed after metastasis: absolute burden and deaths potentially avoidable through earlier detection. These findings have implications for risk prevention for women at increased risk of breast cancer. A., Geisler, J., Giles, G. G., Grip, M., Gndert, M., Hahnen, E., Haiman, C. A., Hkansson, N., Hall, P., Hamann, U., Hartikainen, J. M., Heemskerk-Gerritsen, B. Younger women were more likely to report some type of counseling, controlling for other factors: odds ratio, 4.5 (95% CI, 2.6 to 8.0); 1.9 (95% CI, 1.1 to 3.3); and 1.5 (95% CI, 1.0 to 2.3) for women younger than 50 years of age, 50 to 59 years of age, and 60 to 69 years of age versus those 70 years of age and older. Subjects will be assigned to Lower rates of maximal discomfort were reported with mammogram [2.8% (0-14.5%)] and MRI [5.6% (0-18.7%)] than with DL [28.6% (14.6-46.3%)], with P = 0.035.Most high-risk women tolerated intensive breast screening well; they were not more inclined towards PM after participating. Patients and Methods We surveyed 5,080 patients between the ages of 20 and 79 years, diagnosed from July 2013 to August 2015 with early-stage breast cancer and reported to the SEER registries of Georgia and Los Angeles County. Patients (N=37349) had RS results of whom 714 had BRCA1, BRCA2, CHEK2, ATM, PALB2, or Lynch syndrome (MLH1, MSH2, MSH6, PMS2) PVs. The adjusted percentage treated and adjusted odds ratio (OR) are reported based on multivariable modeling for each treatment-eligible group.A total of 20568 women (17.3%) of 119198 were eligible (mean [SD] age, 51.4 [12.2]). In a fragmented health care system, research can be challenging when one seeks to follow cancer patients as they seek care which can continue for months or years and may reflect many physician and patient decisions. He played a key role in bringing Oracle 9i application server to market. B., Kurian, A. W., Domchek, S. M., Garber, J. n., Lancaster, J. n., Weitzel, J. N., Gutin, A. n., Lanchbury, J. S., Robson, M. n. Reply to Residual confounding threatens the validity of observational studies on breast cancer local therapy. We have additionally conducted a literature review to include other Asian countries mainly in Central and Western Asia. A., Troester, M. A., Vachon, C. M., van Veen, E. M., Wang, X. n., Weinberg, C. R., Weltens, C. n., Willett, W. n., Winham, S. J., Wolk, A. n., Yang, X. R., Zheng, W. n., Ziogas, A. n., Dunning, A. M., Pharoah, P. D., Schmidt, M. K., Kraft, P. n., Easton, D. F., Milne, R. L., Garca-Closas, M. n., Chang-Claude, J. n. Association of a Polygenic Risk Score With Breast Cancer Among Women Carriers of High- and Moderate-Risk Breast Cancer Genes. The impact of obesity and body fat distribution on breast cancer patients' risk of death may vary across racial/ethnic groups. We sought to improve understanding of MBC care and its correlates by analyzing real-world claims data using a search engine with a novel query language to enable temporal electronic phenotyping.Using the Advanced Cohort Engine, we identified 6,180 women who met criteria for having estrogen receptor-positive, human epidermal growth factor receptor 2-negative MBC from IBM MarketScan US insurance claims (2007-2014). Ninety-one percent spoke English at home, 70.1% had health insurance, and 67% had access to home internet. Allison Kurian is a leading medical oncologist with expertise in the area of clinical cancer genetics and epidemiology with a focus on women at high risk for developing breast cancers. View details for PubMedID 33426465 To provide more conclusive evidence regarding the role of HOXB13 in breast cancer susceptibility, we here evaluated the association between HOXB13 mutations and increased breast cancer risk within 81 studies of the international Breast Cancer Association Consortium containing 68,521 invasive breast cancer patients and 54,865 controls. They have also lived in Akron, OH and Knoxville, TN 2017 - Discover Kurian Strongest Humans Sweatshirt, a custom product made just for you by Teespring Companies People Investors Funding Rounds Acquisitions Schools Events Hubs Saved William Foust*, Dane County Circuit Court September 9, 2020 Dear Colleagues, As infectious diseases physicians and researchers . 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